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SignificanceHere we describe a fully functional gene drive system constructed in a major worldwide crop pest, Drosophila suzukii. This system is composed of a synthetic Medea drive with a maternal miRNA “toxin” and a zygotic “antidote,” and we demonstrate that it can bias inheritance with 100% efficiency and can persist in a population given high release frequencies. We discuss how such a system may be used to suppress D.
Synthetically Engineered Medea Gene Drive System in the Worldwide Crop Pest, D. suzukii Anna Buchman, John Marshall, Dennis Ostrovski, Ting Yang, Omar S Akbari bioRxiv 162255; doi: https://doi.org/10.1101/162255
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