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Denny Trimcev

As seen in: PLOS Biology, BioRxiv
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Articles

Extreme diversity of phage amplification rates and phage-antibiotic interactions revealed by PHORCE

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By Yuval Mulla, Vrije Universiteit, Janina Müller, Denny Trimcev
| PLOS Biology Verified
Citation: Mulla Y, Müller J, Trimcev D, Bollenbach T (2025) Extreme diversity of phage amplification rates and phage–antibiotic interactions revealed by PHORCE. PLoS Biol 23(4): e3003065. https://doi.org/10.1371/journal.pbio.3003065 Academic Editor: Jeremy J. Barr, Monash University, AUSTRALIA Received: July 4, 2024; Accepted: February 12, 2025; Published: April 8, 2025 Copyright: © 2025 Mulla et al.
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Extreme diversity of phage amplification rates and phage-antibiotic interactions revealed by PHORCE

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By Yuval Mulla, Janina Müller, Tobias Bollenbach, Denny Trimcev
| BioRxiv
Abstract Growth rate plays a fundamental role in microbiology and serves as an important proxy for fitness in evolution. While high-throughput measurements of bacterial growth rates are easily performed in any microbiology lab, similar methods are lacking for phages. This gap hinders systematic comparisons of important phage phenotypes, such as their amplification rate in bacterial populations and their bactericidal effect, across different phages and environmental conditions.
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