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D'Erick P Underwood on Muck Rack

D'Erick P Underwood

As seen in: BioRxiv
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Articles

Mu-opioid receptor knockout on Foxp2-expressing neurons reduces aversion-resistant alcohol drinking

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By Harrison M Carvour, Charlotte Roemer, D'Erick P Underwood, Edith Padilla
| BioRxiv
Abstract Mu-opioid receptors (MORs) in the amygdala and striatum are important in addictive and rewarding behaviors. The transcription factor Foxp2 is a genetic marker of intercalated (ITC) cells in the amygdala and a subset of striatal medium spiny neurons (MSNs), both of which express MORs in wild-type mice and are neuronal subpopulations of potential relevance to alcohol-drinking behaviors.
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Mu-opioid receptor knockout on Foxp2-expressing neurons leads to reduced aversion-resistant reward seeking

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By Charlotte Roemer, Edith Padilla, Harrison M Carvour, D'Erick P Underwood
| BioRxiv
Abstract Mu-opioid receptors (MORs) in the amygdala and striatum are important in addictive and rewarding behaviors. Foxp2 is a marker of intercalated (ITC) cells in the amygdala and a subset of striatal medium spiny neurons (MSNs), both of which express MORs in wild-type mice. For the current series of studies, we characterized the behavior of mice with genetic deletion of the MOR gene Oprm1 in Foxp2-expressing neurons (Foxp2-Cre/Oprm1fl/fl).
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