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Derrien Heloise

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Articles by Derrien Heloise

Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors

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By Daniele Musiani, Hatice Yücel, Marie Vallette, Annapaola Angrisani, Rania El Botty, Bérèngere Ouine, Niccolo Schintu, Caroline Adams, Manon Chevalier, Derrien Heloise, Ahmed El Marjou, Ivan Nemazanyy, Marie Regairaz, Elisabetta Marangoni, Daniele Fachinetti, Raphael Ceccaldi
| Cell Press Verified
keywords nuclear NAD+ SMUG1/UNG crosstalk replication stress dUTP DNA incorporation genomic instability PARP1 hyperactivation uracil excision repair HR-deficient breast and ovarian tumors synthetic lethality PARPi resistance Introduction The synthetic lethality between poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) and BRCA1/2 mutations1,2 has been exploited in the clinic with the approval of PARPis for the treatment of BRCA1/2-mutated tumors,3 also referred to as homologous...
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