Devandran Apparasamy on Muck Rack

Devandran Apparasamy

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Articles

Exploring the Antiamoebic Potential of Zonisamide and Perampanel against Naegleria fowleri: Insights from In Vitro and Docking Studies

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By Kavitha Rajendran, Lemmuel L. Tayo, Marineil Gomez, Devandran Apparasamy
| ACS Publications
This study investigated the antiamoebic potential of two FDA-approved CNS drugs, Zonisamide and Perampanel, against N. fowleri , the causative agent of PAM. At a concentration of 200 μg/mL, Perampanel reduced trophozoite viability by 87.5%, while Zonisamide achieved a 77.3% reduction. Importantly, both compounds exhibited low to moderate cytotoxicity on HeLa and SH-SY5Y cell lines, suggesting a viable therapeutic window.
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