Devika D. Kannambadi on Muck Rack

Devika D. Kannambadi

As seen in: Nature
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Articles

MYOD1 mutation drives cancer stem cell pathways and therapy-resistance in spindle cell/sclerosing rhabdomyosarcoma

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By Yun Wei, Sabateeshan Mathavarajah, Diego Antelo, Shuze Wang, Jihee Lee, Qian Qin, Sara Danielli, Tiffany Eng, Alexandra Veloso, Yueyang Wang, Chuan Yan, Valerie Shiwen Yang, Anand Patel, Selene C. Koo, Patience Odeniyide, Christine A. Pratilas, Miguel Rivera, Esther Rheinbay, David M. Langenau, Alexander Daiki Weissman, Devika D. Kannambadi, Elisa J. Quantin, Gunnlaugur P. Neilsen
| Nature
Abstract Tumor growth and relapse are often driven by cancer stem cells, but self-renewal mechanisms and genetic mutations that elevate their number are not fully understood. Here, we show that recurrent L122R mutation (Leucine to Argine change at amino acid 122) in the DNA-binding site of the Myogenic Differentiation 1 (MYOD1) transcription factor increases cancer stem cell frequency in aggressive Spindle cell/sclerosing rhabdomyosarcoma.
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