Devon Fitzgerald on Muck Rack

Devon Fitzgerald

As seen in: Microbiology Research, Texas Medical Center

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Articles

"Two Mechanisms of Chromosome Fragility at Replication-Termination Site" by Qian Mei, Devon M Fitzgerald et al.

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By Qian Mei, Devon Fitzgerald, Jingjing Liu, Jun Xia
| Texas Medical Center
Keywords Chromosome Fragility, DNA, DNA Replication, DNA, Cruciform, Escherichia coli, Genomic Instability, Humans, Neoplasms Abstract Chromosomal fragile sites are implicated in promoting genome instability, which drives cancers and neurological diseases. Yet, the causes and mechanisms of chromosome fragility remain speculative. Here, we identify three spontaneous fragile sites in the Escherichia coli genome and define their DNA damage and repair intermediates at high resolution.
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Mapping the Escherichia coli DnaA-binding landscape reveals a preference for binding pairs of closely spaced DNA sites

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By Anne M. Stringer, Devon Fitzgerald, Joseph Wade, at Albany
| Microbiology Research
Article metrics loading... /content/journal/micro/10.1099/mic.0.001474 Download as PowerPoint /deliver/fulltext/micro/170/7/mic001474.html?itemId=/content/journal/micro/10.1099/mic.0.001474&mimeType=html&fmt=ahah References Skarstad K, Boye E. The initiator protein DnaA: evolution, properties and function. Biochim Biophys Acta 1994; 1217:111–130 [View Article] [PubMed] [Google Scholar] Leonard AC, Grimwade JE. Regulation of DnaA assembly and activity: taking directions from the genome.
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