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Deyao Yin

As seen in: Wiley Online Library, BioRxiv
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Articles

Rapaprotin, an Endopeptidase‐Activated Proteasome Inhibitor that Induces 26S Disassembly

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By Hanjing Peng, Zufeng Guo, Wei Wang, Deyao Yin
| Wiley Online Library Verified
Conflict of Interests A patent application covering rapaprotin and analogs with J.O.L., H.P., Z.G., C.B.G., W.L.M. as coinventors has been filed by Johns Hopkins University and licensed to Rapafusyn Pharmaceuticals Inc., of which J.O.L. is a board member and equity holder. The arrangement has been reviewed and approved by the Johns Hopkins University in accordance with its conflict-of-interest policies.
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Rapaprotin is Activated by an Endopeptidase to Disassemble 26S Proteasome

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By Hanjing Peng, Zufeng Guo, Wei Wang, Deyao Yin
| BioRxiv
Abstract The 19S regulatory particle (RP) associates with the 20S core particle (CP) to form the 26S proteasome, an evolutionarily conserved holoenzyme that plays key roles in both physiological and pathological processes. Proteasome inhibitors that target the catalytic subunits within the 20S have proven to be valuable research tools and therapeutics for various cancers.
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