Deyarina Gonzalez

Abstract Ovarian cancer is responsible for the most deaths of all gynaecological cancers in the Western world. The symptoms of ovarian cancer are typically subtle and alike to less lethal diseases found more prevalently in the population, frequently resulting in late diagnoses and advanced tumour stages upon treatment initiation.

Abstract Epithelial-to-mesenchymal transition (EMT) plays a key role in the progression of cancer tumours, significantly reducing the success of treatment. EMT occurs when a cell undergoes phenotypical changes, resulting in enhanced drug resistance, higher cell plasticity, and increased metastatic abilities. Here, we employ a 3D agent-based multiscale modelling framework using PhysiCell to explore the role of EMT over time in two cell lines, OVCAR-3 and SKOV-3.

Abstract Epithelial-to-mesenchymal transition (EMT) plays a key role in the progression of cancer tumours and can make treatment significantly less successful for patients. EMT occurs when a cell gains a different phenotype and possesses different behaviours to those previously exhibited. This may result in enhanced drug resistance, higher cell plasticity, and increased metastatic abilities.