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Deying Gong

As seen in: Frontiers, Royal Society of Chemistry
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Articles

Rapid quantification and validation of etomidate and dexmedetomidine blood concentrations in rats using a novel portable mass spectrometer

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By Sicheng Liu, Xiaoxiao Li, Deying Gong, Yanhua H. Huang, Wensheng Zhang
| Frontiers
ORIGINAL RESEARCH article Volume 12 - 2025 | https://doi.org/10.3389/fvets.2025.1696093 1 Introduction To address the challenge of controlling the depth of anesthesia, therapeutic drug monitoring (TDM) applies pharmacokinetic principles by measuring drug concentrations in the blood, enabling individualized and precise dosing to maintain drug levels within a target therapeutic range—thereby optimizing efficacy while minimizing toxicity (1, 2).
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Effects of bolus injection rate on the pharmacodynamics and pharmacokinetics of propofol, etomidate and sufentanil in rats

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By Sicheng Liu, Deying Gong, Xiaoxiao Li, Feng Qiu, Wensheng Zhang
| Frontiers
ORIGINAL RESEARCH article Volume 12 - 2025 | https://doi.org/10.3389/fvets.2025.1696260 This article is part of the Research TopicIntegrated PK/PD and Drug Metabolism Approaches in Drug Development and EvaluationView all 14 articles 1 Introduction Innovative drug research and development (R&D) is widely recognized as a high-risk, high-reward endeavor that demands substantial time and financial investment.
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Long-term sciatic nerve block lead by supramolecular arrangement of self-delivery local anesthetic nano systems

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By Lei Tang Verified, Feng Qin, Deying Gong, Yu Dong
| Royal Society of Chemistry Verified
Long-term sciatic nerve block lead by supramolecular arrangement of self-delivery local anesthetic nano systems Lei Tang, Feng Qin, Deying Gong, Yu Dong, Lili Pan, Changcui Zhou, Qinqin Yin, Xinghai Song, Rui Ling, Junlong Huang, Qin Fan, Wenhao Yi, Fengbo Wu, Xiaoai Wu, Weiyi Zhang, Jun Yang and Jiyu Wang Abstract Classical local anesthetics are unsuitable to treat regional pain lasting several days due to their limited duration and systemic toxicity.
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