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Dharmarajan Sriram on Muck Rack

Dharmarajan Sriram

As seen in: Taylor & Francis Online, ACS Publications
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Articles

Synthesis, Characterization, and Anti-TB Application of Redox-Active Ethyl Carbazate-Derivatized Phenanthroline and Its Silver Complexes

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By Aishwarya Natarajan, Jyothi Kumari, Dharmarajan Sriram, Ravallika Aluri
| ACS Publications
1. Introduction Click to copy section linkSection link copied! The development of new bioactive compounds remains a key research focus to address the growing need for effective treatments against bacterial infections. This demand is driven by bacterial and cellular mutations, along with the increasing drug resistance that common therapeutic drug molecules face. (1−3) Tuberculosis (TB) is an infectious disease caused by exposure to the bacterium Mycobacterium tuberculosis (Mtb).
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Novel quinoline-imidazole derivatives as inhibitors of Mycobacterium tuberculosis: an integrated approach combining molecular dynamics and in-vitro studies: Molecular Simulation: Vol 0, No 0 - Get Access

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By Shankar Alegaon, Dharmarajan Sriram, Neha Khebude, Shriram D. Ranade
| Taylor & Francis Online
ABSTRACT The rationale for designing and synthesising quinoline–imidazole hybrids as antitubercular and cytotoxic agents stems from the strategic combination of two bioactive structural motifs to create compounds with enhanced efficacy, dual targeting, and potential to overcome drug resistance challenges in tuberculosis treatment. Herein, we report the design and synthesis of quinoline–imidazole hybrids. FTIR, Mass, 1H-NMR and 13C-NMR spectral data characterised the synthesised compounds.
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By Pushkar Kulkarni, Swapna Yellanki, Raghavender Medishetti, Dharmarajan Sriram, Uday Saxena, Perumal Yogeeswari
| secure.jbs.elsevierhealth.com
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