Dharshini Ganeshan on Muck Rack

Dharshini Ganeshan

As seen in: Nature
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Articles

Adaptation of hypothalamic CRH neuron responses to stress and pup cues during motherhood

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By Dharshini Ganeshan, David R. Grattan, Karl J. Iremonger, Joon S. Kim
| Nature
Abstract The adaptation of stress responses during motherhood is critical for the well-being of the mother and the offspring. Stress responses are controlled by corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus. Although it is commonly believed that the activity of CRH neurons is dampened during motherhood, this hypothesis has not been directly tested.
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Direct modulation of CRH nerve terminal function by noradrenaline and corticosterone.

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By Emmet Power, Dharshini Ganeshan, Wataru Inoue, Jamieson Paul
| biorxiv.org
Abstract Nerve terminals are the final point of regulation before neurosecretion. As such, neuromodulators acting on nerve terminals can exert significant influence on neural signalling. Hypothalamic corticotropin-releasing hormone (CRH) neurons send axonal projections to the median eminence where CRH is secreted to stimulate the hypothalamic-pituitary-adrenal (HPA) axis.
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Estradiol regulates voltage-gated potassium currents in corticotropin-releasing hormone neurons

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By Emmet Power, Dharshini Ganeshan, Karl John Iremonger
| biorxiv.org
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