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Dhatchayini Subramani on Muck Rack

Dhatchayini Subramani

As seen in: Nature
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Articles

Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis

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By Jagadananda Ghosh, Jitender Monga, Dhatchayini Subramani, Ajay Bharathan
| Nature Verified
Abstract Much of the morbidity and mortality due to prostate cancer happen because of castration-resistant prostate cancer (CRPC) which invariably develops after anti-androgenic therapy. FDA-approved enzalutamide is commonly prescribed for CRPC which works by blocking androgen receptor function. However, even after initial good response, enzalutamide-resistant prostate cancer (ERPC) develops which eventually leads to widespread metastasis.
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