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Dheraj Taheem on Muck Rack

Dheraj Taheem

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Articles

iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors

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By Yaobo Xu, Min Yu, Dario Melguizo-Sanchis, Dheraj Taheem
| Nature Verified
To generate an in vitro disease model for SAA, dermal fibroblasts cells from 1 pediatric and 2 young adult cases of idiopathic SAA, showing severe and very severe clinical manifestation and no clinical stigmata of constitutional AA as well as three unaffected controls (indicated as WT throughout the manuscript) were transduced with the non-integrating RNA-derived Sendai virus (SeV) vector including the four Yamanaka reprogramming factors (OCT4, SOX2, KLF4, c-MYC) as previously reported17...
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