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Investigating DNA contamination affecting embryo biopsy specimens taken for PGT-A: Incidence and impact on the accuracy of chromosomal analysis
ArticleArticles in Press105637 Affiliations & Notes 1Juno Genetics, Oxford, United Kingdom 2University of Oxford, Nuffield Department of Women's and Reproductive Health, Oxford, United Kingdom 3Juno Genetics, Valencia, Spain 4Juno Genetics, Rome, Italy Article Info Publication History: Received August 26, 2025; Revised January 14, 2026; Accepted February 13, 2026; Published online February 19, 2026 DOI: 10.1016/j.rbmo.2026.105637 External LinkAlso available on ScienceDirect External Link...
Maternal age and genome-wide failure of meiotic recombination are associated with triploid conceptions in humans
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Results To determine the incidence of ploidy abnormalities in human preimplantation embryos, we used data obtained from 96,660 trophectoderm biopsies (dataset A; see subjects, material, and methods and Table S1) from 20,187 IVF cycles that used a targeted NGS protocol for PGT for aneuploidy (PGT-A) or monogenic (PGT-M) disorders (Figure 1).
By Ludovica Picchetta, Christian Ottolini, Xin Tao, Yiping Zhan, Vaidehi Jobanputra, Carlos Marin Vallejo, Francesca Mulas, Elvezia Maria Paraboschi, Thomas Molinaro, Christine Whitehead, Pavan Gill, Emily Mounts, Dhruti Babariya, Laura Rienzi, Filippo Ubaldi, Juan Garcia-Velasco, Antonio Pellicer, Shai Carmi, Eva Hoffmann, Antonio Capalbo
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The American Journal of Human Genetics
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