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Articles by Di Ran
The Gut-Lung Microbiome Axis in Alveolar Stem Cell Regeneration and Lung Repair
You are already at the latest version The mammalian respiratory system stands as a frontline barrier, constantly exposed to environmental insults, balancing defensive immunity with gas exchange. Historically considered sterile, the lung harbors a dynamic, low-biomass microbiome that evolves con-tinuously in response to pulmonary pathologies.
Sa1447 INTESTINAL EPITHELIAL CELL-SPECIFIC AXIN1 DEFICIENCY PROTECTS MITOCHONDRIAL FUNCTION AND MAINTAINS BARRIER INTEGRITY DURING INFLAMMATION
Also available on ScienceDirect
Mo1762 TAUOPATHY DISRUPTS GUT AND BRAIN BARRIERS AND SUPPRESSES β-CATENIN IN ALZHEIMER’S DISEASE
Also available on ScienceDirect
Su1476 MACROPHAGE VITAMIN D RECEPTOR DEFICIENCY IMPAIRS MITOCHONDRIAL FUNCTION AND WEAKENS HOST DEFENSE AGAINSTINFLAMMATION AND FUNGI INFECTION
Also available on ScienceDirect
New Methods for Two‐Stage Treatment Switching Estimation
1 Introduction Treatment switching [1, 2] is common in randomized trials of oncology treatments. This occurs when a patient ceases to receive their randomized treatment and instead receives an alternative subsequent therapy. For example, switching to the experimental treatment may be permitted in the control arm in the situation where the experimental treatment has been shown to be effective in interim analyses.
Relative Performance of Frequentist and Bayesian Methods for Incorporating External Controls: A Case Study with Patient Level Data from the DapaHF Trial
Abstract Some populations, such as rare diseases, cannot be studied in randomized clinical trials due to feasibility or ethical considerations. One way to address this is to incorporate external data to augment what is learned in the trial about a standard of care control arm. Statistically, there are two broad families of approaches for incorporating external controls for comparisons, propensity score-based methods (PSM) and Bayesian dynamic borrowing (BDB) methods.
Tutorial on Firth's Logistic Regression Models for Biomarkers in Preclinical Space
Conflicts of Interest G.D. and D.R. are employees of AstraZeneca and may have stock ownership, options, or interests in the company. Supporting Information Filename Description pst2422-sup-0001-SupinfoS1.docxWord 2007 document , 23.5 KB Data S1. Supporting Information. data1_all_bin.csvapplication/csv, 473 B Data S2. Supporting Information. data2_cont_bin.csvapplication/csv, 1.5 KB Data S3. Supporting Information. data3_comb.csvapplication/csv, 295 B Data S4. Supporting Information.
Tutorial on Firth's Logistic Regression Models for Biomarkers in Preclinical Space
Conflicts of Interest G.D. and D.R. are employees of AstraZeneca and may have stock ownership, options, or interests in the company. Supporting Information Filename Description pst2422-sup-0001-SupinfoS1.docxWord 2007 document , 23.5 KB Data S1. Supporting Information. data1_all_bin.csvapplication/csv, 473 B Data S2. Supporting Information. data2_cont_bin.csvapplication/csv, 1.5 KB Data S3. Supporting Information. data3_comb.csvapplication/csv, 295 B Data S4. Supporting Information.
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