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DIAMONDS Consortium

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Articles

Genomic investigations of unexplained acute hepatitis in children - Nature

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By Sarah J Buddle, José Afonso Guerra-Assunção, Moradi Marjaneh, Nathaniel Storey, Luis A. Campos, Luís Campos, John R. Counsell, Gabriele Pollara, Luke J. Tappouni, Alexander Lennon, Andrew J. McArdle, Joshua Rosenheim, Helena Tutill, Catherine Moore, Colin Fink, Giorgia Santilli, Paul Gissen, Cristina C. Celma, Kenneth Baillie, Malcolm Gracie Semple, DIAMONDS Consortium, Ines Ushiro-Lumb, Mahdad Noursadeghi, Konstantinos Thalassinos, Simon Waddington, Emma Thomson, Michael Levin
| Nature
Abstract Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods.
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