Diansong Zhou

Abstract Population pharmacokinetic (PopPK) models are crucial for understanding drug behaviour across populations, yet traditional development is often labour-intensive and slow. This study demonstrates an automated, out-of-the-box approach for popPK model development, leveraging optimisation algorithms implemented using pyDarwin to efficiently handle a diverse range of extravascular drugs.

Bispecific antibodies (BsAbs) offer several advantages over traditional monoclonal antibodies (mAbs) by enabling the targeting of more than one disease-associated antigen or simultaneously engaging immune effector cells.1, 2 The first BsAb (catumaxomab) was approved in 2009 for the treatment of malignant ascites.3 Though it was withdrawn from the market in 2017 for commercial reasons,4 catumaxomab demonstrated that targeting both tumor antigen (epithelial cell adhesion molecule) and T cells...

Simplified Aztreonam Dosing in Patients with End-Stage Renal Disease: Results of a Monte Carlo Simulation Alan E. Gross, Hongmei Xu, Diansong Zhou, Nidal Al-Huniti Antimicrobial Agents and Chemotherapy Oct 2018, 62 (11) e01066-18; DOI: 10.1128/AAC.01066-18