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Ferroptosis is an iron-dependent form of regulated cell death characterized by the lethal accumulation of lipid hydroperoxides on cellular membranes (Dos Santos et al., 2023). Its biochemical core involves three interacting layers. First, labile ferrous iron (Fe2+) catalyzes Fenton chemistry that generates hydroxyl radicals from hydrogen peroxide, initiating lipid-radical cascades.
CRC stands as one of the predominant causes of mortality globally, posing a significant health risk. Butyrate, a saturated SCFA derived from the microbial fermentation of dietary fiber, exhibits potential in suppressing tumorigenesis (Hanus et al., 2021), yet its precise mechanisms in CRC require further elucidation. Our study employed bioinformatic approaches to identify six BMGs as candidate diagnostic biomarkers for CRC (Li et al., 2024).
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