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Diego Barriales

As seen in: Nature, PLOS Biology, Future Medicine
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Articles

Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation - Communications Biology

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By Aize Pellon, Janire Castelo, Diego Barriales, Hector Rodriguez, Héctor Rodríguez, Juan Anguita, Ainize Peña-Cearra, Naiara Gutiez
| Nature Verified
Abstract The initial exposure to pathogens and commensals confers innate immune cells the capacity to respond distinctively upon a second stimulus. This training capacity might play key functions in developing an adequate innate immune response to the continuous exposure to bacteria. However, the mechanisms involved in induction of trained immunity by commensals remain mostly unexplored. A. muciniphila represents an attractive candidate to study the promotion of these long-term responses.
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Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression - npj Biofilms and Microbiomes

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By José Luis Lavín, Diego Barriales, Asier Fullaondo, Ana M. Aransay, Hector Rodriguez, Héctor Rodríguez, Juan Anguita, Janire Castelo
| Nature Verified
Abstract Recent evidence demonstrates potential links between mitochondrial dysfunction and inflammatory bowel diseases (IBD). In addition, bidirectional interactions between the intestinal microbiota and host mitochondria may modulate intestinal inflammation. We observed previously that mice deficient in the mitochondrial protein MCJ (Methylation-controlled J protein) exhibit increased susceptibility to DSS colitis.
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Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart

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By Diego Barriales, Itziar Martín-Ruiz, Ana Carreras-González, Marta Montesinos-Robledo
| PLOS Biology Verified
Loading metrics Open Access Peer-reviewed Research Article Diego Barriales, Itziar Martín-Ruiz, Ana Carreras-González, Marta Montesinos-Robledo, Mikel Azkargorta, Ibon Iloro, Iraide Escobés, Teresa Martín-Mateos, Estibaliz Atondo, Ainhoa Palacios, Monika Gonzalez-Lopez, Laura Bárcena, Ana R. Cortázar, Diana Cabrera, Ainize Peña-Cearra, Sebastiaan M. van Liempd, Juan M. Falcón-Pérez, Miguel A. Pascual-Itoiz, Juana María Flores, Leticia Abecia, Aize Pellon, Maria Luz Martínez-Chantar, Ana M.
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