Dien Nguyen

Abstract Click to copy section linkSection link copied! Nanosizing drug particles has emerged as a successful approach to enable the oral bioavailability of lipophilic small molecule drugs. Scalable “bottom-up” methods have been developed to overcome the limitations and resource-intensiveness of traditional “top-down” nanoparticle production.

Dien Nguyen · Follow 4 min read · -- The recent controversy surrounding Ryann Juden, the former city manager of North Las Vegas, has raised significant ethical questions regarding his post-employment actions. This situation highlights the complexities of public service and the potential for conflicts of interest when officials transition to private sector roles. The Nevada Ethics Commission has become involved, prompting a closer examination of the events leading to this scandal.

Abstract Ionizable lipids are a key component of lipid nanoparticles, the leading nonviral messenger RNA delivery technology. Here, to advance the identification of ionizable lipids beyond current methods, which rely on experimental screening and/or rational design, we introduce lipid optimization using neural networks, a deep-learning strategy for ionizable lipid design.