Dilver Peña Fuentes

Abstract The catalytic hydrogenation of amides continues to be one of the most difficult reductive transformations in organic synthesis. Despite significant efforts in past decades, there is no general protocol reported allowing the synthesis of various primary amines from the corresponding primary amides using molecular hydrogen. To perform this challenging reaction, here we report a specific homogeneous ruthenium catalyst based on the methoxy-substituted triphos ligand (Triphos(p-anisole)).

Journal of the American Chemical Society Cite this: J. Am. Chem. Soc. 2025, XXXX, XXX Click to copy citationCitation copied! . This publication is licensed under CC-BY 4.0 . You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.

Catalyst Development and Optimization of the Reaction System In order to develop a general synthesis methodology for primary amines from readily accessible esters and acids, the direct amination of methyl benzoate with ammonia in the presence of molecular hydrogen was utilized as a model reaction. Traditional reductive aminations of carbonyl compounds have predominantly been carried out by employing heterogeneous noble metal-based materials.