Dinesh Pal Mudaranthakam

Supplement 1. eMethods 1. Bayesian Spatiotemporal Beta Regression Model (ICAR Spatial + AR(1) Temporal Effects) eMethods 2. Multiple-Mediator Structural Equation Model (SEM) for 2024 (HOLC Grade D vs Grades A–C) eFigure 1. Data Cleaning and Census Tract Selection Flowchart for the Bayesian Spatiotemporal Beta Regression Analyses eFigure 2. Posterior Temporal Random Effects, 2016-2024 eFigure 3. Tract-Year Classification Relative to Healthy People 2030 Benchmark (≥80.3%), 2016–2024 eTable.

1 BACKGROUND Financial toxicity refers to the financial burden and distress associated with illness and care, including out‑of‑pocket expenses, lost income, debt, and depletion of household resources. Dementia imposes not only profound emotional and physical challenges for patients and families, but also a substantial and often underrecognized economic burden. Although financial toxicity can affect both patients and caregivers, its manifestations differ across these groups.

The University of Kansas Cancer Center (KU Cancer Center) serves a population that extends across rural and urban counties of Kansas and 18 counties of western Missouri that lay along the state border. Monitoring population-level demographic, screening, risk factor, and cancer incidence and/or mortality data across the bistate catchment area requires data merging and normalization across state-level data resources.