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Articles by Dingfeng Li
Glucocorticoid-Induced Adrenal Insufficiency
This has been adapted from an article originally published in Cleveland Clinic Journal of Medicine, Vol. 91, April 2024. The original can be found . Advertisement Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy By Noura Nachawi, MD, Dingfeng Li, MD, and M.
Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization
Cogliati S. Enriquez J.A. Scorrano L. Mitochondrial cristae: where beauty meets functionality. Trends Biochem. Sci. 2016; 41: 261-273 Daum B. Walter A. Horst A. Osiewacz H.D. Kühlbrandt W. Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria. Proc. Natl. Acad. Sci. USA. 2013; 110: 15301-15306 Andersen J.V. Schousboe A. Verkhratsky A. Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle. Prog.
Brain cell type-specific cholesterol metabolism and implications for learning and memory
Zhang J. Liu Q. Cholesterol metabolism and homeostasis in the brain. Protein Cell. 2015; 6: 254-264 Barber C.N. Raben D.M. Lipid metabolism crosstalk in the brain: glia and neurons. Front. Cell. Neurosci. 2019; 13: 212 Jin U. et al. Cholesterol metabolism in the brain and its association with Parkinson's disease. Exp. Neurobiol. 2019; 28: 554-567 Camargo N. et al. Oligodendroglial myelination requires astrocyte-derived lipids. PLoS Biol. 2017; 15e1002605 Chanaday N.L. et al.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory
Highlights • Astrocytic ApoE vectors miRNA species that silence neuronal cholesterol biosynthesis • Astrocytic ApoE promotes acetyl-CoA, histone acetylation, and transcription in neurons • Memory consolidation is potentiated by ApoE-mediated epigenetic control in the brain • ApoE4 is less capable of metabolic and epigenetic regulation in neurons than ApoE3 Summary Astrocytes metabolically interact with neighboring neurons by providing multiple substances to neurons.
Epidemiology of adrenal tumours in Olmsted County, Minnesota, USA: a population-based cohort study
Summary Background Adrenal tumours are commonly encountered in clinical practice, but epidemiological data mainly originate from referral centres. We aimed to determine incidence, prevalence, and rates of malignancy and hormone excess in patients with adrenal tumours in a standardised geographically well defined population.
Activity dependent LoNA regulates translation by coordinating rRNA transcription and methylation
Long-term memory is a fundamental cognitive process, requiring gene expression and protein synthesis for memory consolidation15. The biosynthesis of rRNA is essential in the production of functional ribosomes. To elucidate the role of rRNA in learning and memory, we have examined rRNA levels in mice with experience-induced memory formation using the Morris water maze and found that both pre-rRNA and mature rRNA levels were significantly elevated in trained mice as compared to controls (Fig.
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