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Articles by Dinghao Chen
Computer Science > Robotics
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Modular peptide nanofibres that self-assemble on bacterial membranes overcome antimicrobial resistance
Abstract Drug-resistant bacterial infections increasingly evade available antimicrobials, and many existing antimicrobial peptides remain limited by instability, toxicity to mammalian membranes and high manufacturing cost.
Bone homeostasis regulation by in vivo generation of osteoclast-derived apoptotic bodies using targeted self-assembly - Nature Communications
Abstract Osteoporosis therapies remain limited by non-specific osteoclast inhibition, which disrupts physiological bone remodeling and increases fracture risk. Here we show that selectively targeting mature osteoclasts via enzyme-responsive nanoparticles could eliminate pathological bone resorption while generating apoptotic bodies (ABs) to promote regeneration.
De novo design of self-assembling peptides with antimicrobial activity guided by deep learning - Nature Materials
Abstract Bioinspired materials based on self-assembling peptides are promising for tackling various challenges in biomedical engineering. While contemporary data-driven approaches have led to the discovery of self-assembling peptides with various structures and properties, predicting the functionalities of these materials is still challenging.
A Two‐Pronged Pulmonary Gene Delivery Strategy: A Surface‐Modified Fullerene Nanoparticle and a Hypotonic Vehicle
Communication Dr. Daiqin Chen, The Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Johns Hopkins, Baltimore, MD, USA Department of Ophthalmology, Johns Hopkins University, Baltimore, MD, USA These authors contributed equally to this work.
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