Laicheng Zhou

Abstract Drug-resistant bacterial infections increasingly evade available antimicrobials, and many existing antimicrobial peptides remain limited by instability, toxicity to mammalian membranes and high manufacturing cost.

Abstract Biomolecular condensates, formed by liquid-liquid phase separation (LLPS) of proteins or the complex of protein and nucleic acids, play key roles in regulating physiological events in biological system. However, the formation of mono-component yet inhomogeneous condensates is limited, and the underlying mechanism remains unclear. Here, we report the symmetrical core-shell structural biomolecular condensates formed through the LLPS by programming a tetra-peptide library.

Research Article Dr. Xuejiao Yang, Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University, Institute of Natural Sciences, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou, 310024 Zhejiang Province, China Search for more papers by this author Honglei Lu, Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University, Institute of Natural Sciences,...