Dingxue Cai

Disclosure No conflict of interest exists in the submission of this manuscript, and all authors have approved the manuscript for publication. Supporting Information Filename Description ins70379-sup-0001-SuppMat.pdf5.3 MB Fig. S1 Characterization of DNA methylation-associated proteins in Helicoverpa armigera. Fig. S2 Expression and purification of recombinant DNMT1 and MBD2/3 proteins. Fig. S3 Genome-wide distribution of DNA methylation in H. armigera. Fig. S4 Reproducibility of RNA-seq datasets. Fig.