Diniz Maciel de on Muck Rack

Diniz Maciel de

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Dynamics of the Apo µ-Opioid Receptor in Complex with Gi Protein

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By David Bento, Sena Júnior, Rubem Francisco Silva, Diniz Maciel de
| MDPI
1. Introduction The G Protein-Coupled Receptors (GPCRs) comprise a large group of structures located on the cell plasma membrane that participate in various intracellular signaling pathways, thereby regulating cellular functions such as metabolism, growth, and death [1]. They are the target of 30–50% of commercially available drugs [2]. GPCRs exhibit this versatility due to the variety of biochemical functions they can bind to small molecules, lipids, peptides, and nucleotides [3].
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