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Phenothiazine–Bile Acid Conjugates: A Novel Approach to Combat Gram-Negative Bacterial Resistance Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Gram-negative bacterial resistance continues to pose a major therapeutic challenge, largely due to outer membrane impermeability and biofilm-associated tolerance mechanisms. In this study, we report the rational design, synthesis, and mechanistic characterization of bile acid–phenothiazine (BA–PTZ) conjugates as membrane-targeted antibacterial hybrids.
Functionalized Schiff-base containing phenothiazine and cholic acid as a paper-based fluorescence turn-off sensor for Sn(II) ion detection and its application
Functionalized Schiff-base containing phenothiazine and cholic acid as a paper-based fluorescence turn-off sensor for Sn(ii) ion detection and its application† Employing a one-pot Schiff-base condensation approach, the derivative “cholyl hydrazide Schiff base of phenothiazine” (ChHSB-PTZ) based on cholic acid has been synthesized and characterized via standard procedures.
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