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Heparin-Induced Hyperkalemia Assessment Utilizing the Naranjo Adverse Drug Reaction Probability Scale: A 40-Year Systematic Review

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By Divita Singh, Michael Cawley
| MDPI
1. Introduction Heparin is the oldest anticoagulant used in clinical medicine. Heparin is a naturally occurring polysaccharide belonging to the glycosaminoglycan family. After its discovery by McLean in 1916 as a naturally occurring polysaccharide, the drug went on to be marketed as a pharmaceutical product in the United States in the form of unfractionated heparin (UFH) in 1939 [1,2].
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