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Diying Shen on Muck Rack

Diying Shen

As seen in: Nature
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Articles

Measurable residual disease detected by next-generation sequencing in T-cell acute lymphoblastic leukemia

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By Chan Liao, Haipin Chen, Liyao Xu, Shupeng Lin, Jingying Zhang, Weiqun Xu, Juan Liang, Fenying Zhao, Diying Shen, Heping Shen, Hua Song, Yongmin Tang, Xiaojun Xu
| Nature Verified
Abstract The clinical utility of measurable residual disease monitoring based on next-generation sequencing in T-cell acute lymphoblastic leukemia remains incompletely defined. Here we show the prognostic value of tracking clonal T-cell receptor gene rearrangements by next-generation sequencing in pediatric patients with T-cell acute lymphoblastic leukemia.
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By Qingyuan Xu, Linya Wang, Ning Liao, Mincui Zheng, Yunpeng Dai, Shaoyan Hu, Li Wang, Qun Hu, Xin Tian, Xiaohuan Wang, Yuanyuan Zhang, Pengli Huang, Ying Choon Wu, Wei Lin, Jia Fan, Ruidong Zhang, Yaguang Peng, Huyong Zheng, Diying Shen, Jiaole Yu, Peijing Qi
| Nature Verified
In recent years, the targeted therapy combining arsenic with all-trans retinoic acid (ATRA) has dramatically improved outcomes in pediatric acute promyelocytic leukemia (APL) [1, 2]. However, 5–10% of patients still experience relapse [3], which remains a major barrier to cure. Within this modern therapeutic framework, the risk factors for relapse in pediatric APL—particularly the role of arsenic pharmacokinetics—are not fully defined.
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