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Diyun Sun on Muck Rack

Diyun Sun

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Articles

Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response - Nature Communications

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By James Grissom, Luca Fornelli, Diyun Sun
| Nature Verified
Abstract Cells must respond rapidly to heat stress by activating multiple signaling pathways that preserve proteostasis. In budding yeast, this includes induction of Hsf1 and Msn2/4-mediated transcription, cell integrity signaling, stress-triggered phase separation of proteins, and inhibition of translation. How these pathways are so rapidly activated and coordinated remains unclear.
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