Research in context Evidence before this study Before the TALAPRO-2 trial was started in December, 2017, we searched PubMed for relevant preclinical or clinical research published on DNA damage repair, homologous recombination repair (HRR), so-called BRCAness, novel hormonal therapies or androgen receptor pathway inhibitors (ARPIs), androgen receptor signalling inhibition, poly(ADP-ribose) polymerase (PARP) inhibitors, and advanced prostate cancer to help determine the most appropriate study...