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Doeke R. Hekstra on Muck Rack

Doeke R. Hekstra

As seen in: Nature, MDPI, ACS Publications, Science Magazine
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Articles

AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network

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By Alisia Fadini, Minhuan Li, Airlie J. McCoy, Suresh Banjara, Hiroki Okumura, Pietro Fontana, Amir Khan, Luca Jovine, Thomas C. Terwilliger, Randy Read, Doeke R. Hekstra, Mohammed AlQuraishi, Eve Napier
| Nature Verified
Abstract Advances in machine learning have transformed structural biology, enabling swift and accurate prediction of protein structure from sequence. However, key challenges persist in modeling side-chain packing, condition-dependent conformational changes and biomolecular interactions, largely because of limited high-quality training data.
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VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation

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By Doeke R. Hekstra, David Ottenheimer, Ivana Maric, Bibi Alika Sulaman
| Science Magazine Verified
Abstract Memory consolidation enables animals to draw on past experiences to guide future behavior. This process involves system- and synaptic-level changes and predominantly occurs during sleep. While hippocampal-cortical circuits are well studied in this context, the contributions of other systems, including dopaminergic circuits—key players in learning-related processes—remain poorly understood.
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QUIRKY controls seed germination via precision degradation of ABI5

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By Doeke R. Hekstra, David Ottenheimer, Ivana Maric, Yupeng Jiang
| Science Magazine Verified
Abstract Seed dormancy and germination are dynamically regulated by abscisic acid (ABA), with transcription factor ABA INSENSITIVE 5 (ABI5) serving as a key repressor of germination under stress. Here, we identify QUIRKY (QKY), a MULTIPLE C2 DOMAIN AND TRANSMEMBRANE REGION PROTEIN (MCTP) in Arabidopsis, as a critical regulator of ABA signaling through posttranslational control of ABI5.
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