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Articles by Dominik Handler
Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals
eLife assessment This fundamental work has completed our understanding of the singular binding profile of the Rhino HP1 protein to chromatin, a key step in converting certain genomic regions into piRNA source loci. The evidence supporting the conclusions is compelling.
Evolutionary Adaptation of an HP1-protein Chromodomain Integrates Chromatin and DNA Sequence Signals
Abstract Members of the diverse heterochromatin protein 1 (HP1) family play crucial roles in heterochromatin formation and maintenance. Despite the similar affinities of their chromodomains for di- and tri-methylated histone H3 lysine 9 (H3K9me2/3), different HP1 proteins exhibit distinct chromatin binding patterns, likely due to interactions with various specificity factors.
Spatially resolved proteomics of the Arabidopsis stomatal lineage identifies polarity complexes for cell divisions and stomatal pores
Highlights • Bipolar domains in stomatal asymmetric divisions are reconfigured during differentiation • OPL2 functions during cytokinesis at the pore-forming stomatal wall • Structural predictions show conserved polarity protein interaction interfaces • TurboID-based proximity labeling identifies plant polarity protein partners Summary Cell polarity is used to guide asymmetric divisions and create morphologically diverse cells.
Selfish conflict underlies RNA-mediated parent-of-origin effects - Nature
Abstract Genomic imprinting—the non-equivalence of maternal and paternal genomes—is a critical process that has evolved independently in many plant and mammalian species1,2. According to kinship theory, imprinting is the inevitable consequence of conflictive selective forces acting on differentially expressed parental alleles3,4. Yet, how these epigenetic differences evolve in the first place is poorly understood3,5,6.
Spatially resolved proteomics of the stomatal lineage: polarity complexes for cell divisions and stomatal pores
Abstract Cell polarity is used to guide asymmetric divisions and create morphologically diverse cells. We find that two oppositely oriented cortical polarity domains present during the asymmetric divisions in the Arabidopsis stomatal lineage are reconfigured into polar domains marking ventral (pore-forming) and outward facing domains of maturing stomatal guard cells. Proteins that define these opposing polarity domains were used as baits in miniTurboID-based proximity labeling.
Evolutionary adaptation of the chromodomain of the HP1-protein Rhino allows the integration of chromatin and DNA sequence signals
Abstract Members of the diverse heterochromatin protein 1 (HP1) family of proteins play crucial roles in heterochromatin formation and maintenance. Despite the similar affinities of their chromodomains for di- and tri-methylated histone H3 lysine 9 (H3K9me2/3), different HP1 proteins exhibit distinct chromatin binding patterns, presumably due to their interactions with various specificity factors.
Functional Adaptations of Endogenous Retroviruses to the Drosophila Host Underlie their Evolutionary Diversification
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The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters
Decision letter after peer review: Thank you for submitting your article "The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters" for consideration by eLife. Your article has been reviewed by 3 peer reviewers, and the evaluation has been overseen by a Reviewing Editor and Kevin Struhl as the Senior Editor. The following individual involved in review of your submission has agreed to reveal their identity: Zhao Zhang (Reviewer #2).
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