Dong Hyeok Yoon on Muck Rack

Dong Hyeok Yoon

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Articles

Targeting bacterial influx pathways to defeat antibiotic resistance: fluorinated glucose-6-phosphate analogues revive fosfomycin efficacy

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By Akhilesh Kumar Chaurasia, Joohyun Lee, Tracey Newman, Nicholas Evans, Seung Seo Lee, Kyeong Kyu Kim, Kirsty Alexandra Teahan, Dong Hyeok Yoon, Jacob Bilsborrow
| Nature Verified
Abstract Current adjuvant strategies to combat antimicrobial resistance such as β-lactamase inhibitors and efflux pump blockers prevent antibiotic degradation or export. We introduce a fundamentally different approach: exploiting bacterial nutrient sensing to drive antibiotic influx and overwhelm resistance. Fosfomycin is transported into bacterial cytoplasm via the glucose-6-phosphate (G6P) channel UhpT, which is activated by G6P.
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