Dong In Kim on Muck Rack

Dong In Kim

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Selenium reduction of ubiquinone via SQOR suppresses ferroptosis - Nature Metabolism

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By Namgyu Lee, Sung Jin Park, Tenzin Tseyang, Mihir B. Doshi, Paul L. Greer, James A. Olzmann, Jessica B. Spinelli, Dong In Kim
| Nature Verified
Abstract The canonical biological function of selenium is in the production of selenocysteine residues of selenoproteins, and this forms the basis for its role as an essential antioxidant and cytoprotective micronutrient. Here we demonstrate that, via its metabolic intermediate hydrogen selenide, selenium reduces ubiquinone in the mitochondria through catalysis by sulfide quinone oxidoreductase.
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