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Articles by Dong Xing
Gene regulatory landscape dissected by single-cell four-omics sequencing
Abstract Cellular diversity is governed not only by the transcriptome but also by multiple layers of epigenomic regulation, including nucleosome occupancy, chromatin states and genome architecture1,2,3.
Glycolysis-mediated H3K18la modifications drive aggressive bladder cancer through metabolic and epigenetic reprogramming
Abstract Background: Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of human bladder cancer (BC). Lactate-dependent histone modification represents a novel class of histone marks that links the glycolytic metabolite to the epigenetic mechanism of lactylation. However, the role of histone lactylation in BC remains unclear.
Copper-Catalyzed Asymmetric Carbocyanation of 1,3-Dienes and Vinylarenes with Simple Aldehydes and Alkanes
Cite Jump to ExpandCollapse Research ArticleAugust 22, 2025 Copper-Catalyzed Asymmetric Carbocyanation of 1,3-Dienes and Vinylarenes with Simple Aldehydes and Alkanes Click to copy article linkArticle link copied! Shang Wang Shang Wang Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China...
Selective Oxidation of Benzyl and Allyl Alcohols to Carbonyl Compounds or Acids Mediated by Iron Photocatalysts
Conflict of Interests The authors declare no conflict of interest. Supporting Information Filename Description cctc70038-sup-0001-SuppMat.pdf5.3 MB Supporting Information References 1, , , Nature 1964, 202, 179–181. 2, , , Org. Process Res. Dev. 1999, 3, 363–364. 3, , , , , , , Tetrahedron Lett. 1998, 39, 5323–5326. 4, , Tetrahedron Lett. 2003, 44, 549–552. 5, , , , Org. Lett. 2022, 24, 3499–3503. 6, , , , , , Green Chem. 2012, 14, 1493. 7, , , J. Org. Chem. 2006, 71, 5043–5046. 8, , , , , , , , , , , Mol. Catal.
PUF60‐Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration
1 Introduction Gastric cancer (GC) is the fifth most common cancer type and the fourth leading cause of cancer death globally [1]. Due to the high molecular and phenotypic heterogeneity of GC, surgical resection is the preferred treatment [2]. However, most patients with advanced GC often have lost the opportunity for surgery. Fortunately, the molecular classification of GC has provided an opportunity for patients to receive personalized treatment.
CD2AP shapes a stromal reduced tumor microenvironment and contributes to immunotherapy in gastric cancer - BMC Cancer
Expression profile data normalized as Fragments per Kilobase Million (FPKM) of pan-cancer, along with information concerning somatic mutations and survival outcomes, were retrieved from The Cancer Genome Atlas (TCGA) database (https://portal.gdc.cancer.gov/). RNA sequencing data underwent log2 transformation, and tumor mutational burden (TMB) was computed for somatic mutation data using VarScan2 analysis.
Clarifying the Identity of the m/z 36 Ion in Water Microdroplet Mass Spectra
The Journal of Physical Chemistry A Cite this: J. Phys. Chem. A 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Dynamic changes in 3D chromatin structure during male gametogenesis in Arabidopsis thaliana - Genome Biology
Col-0, pMGH3::MGH3-eGFP/pACT11::H2B-mRFP, pHTR10::HTR10-RFP, and h2b.8 mutant plants were grown in a Percival growth chamber at 22 °C under long-day (16 h light/8 h dark) conditions. To create the h2b.8 mutant, four primers for single-guide RNA (sgRNA) were designed and cloned into the pAtU6-sgRNAs vector [37].
Mechanism of the traditional Chinese medicine Simiao Biejia decoction | DDDT
Back to Journals » Drug Design, Development and Therapy » Volume 19 Authors Liu Y, Sun D , Xing D, Rui Y, Jin Y, Wang P, Cai B, Li C, Gao C, Cui Y, Jin B Received 15 October 2024 Accepted for publication 18 March 2025 Published 3 April 2025 Volume 2025:19 Pages 2609—2628 DOI https://doi.org/10.2147/DDDT.S495366 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Yan Zhu Yuanyuan Liu,1,* Dalin Sun,2,*...
Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor
eLife assessment This useful study draws on published single-cell and spatial transcriptomic data of colon cancer liver metastasis to clarify the pro- and anti-tumorigenic properties of NK cells. The authors discover increased GZMK+ resting NK cells in the tumor tissue and reduced abundance of KIR2DL4+ activated NK cells. However, the evidence is currently incomplete, as the models used to validate the hypothesis and claims are not adequate and lack the necessary controls.
Proton transfer induced excited-state aromaticity gain for chromophores with maximal Stokes shifts
Proton transfer induced excited-state aromaticity gain for chromophores with maximal Stokes shifts Excited state aromaticity (ESA) offers a fascinating route for driving photophysical and photochemical processes but is challenging to harness fully due to its inherent association to unstable antiaromatic ground states.
Asymmetric Alkylative Difunctionalization of Carbon‐Carbon Double Bonds by Aliphatic C-H Bond Activation
This Concept highlights the latest advancements in asymmetric alkylative difunctionalization of carbon-carbon double bonds by utilizing aliphatic C–H substrates as alkyl radical precursors.
Elucidating the non-radiative losses encountered in intramolecular charge transfer compounds with benzodithiophene-4,8-dione acceptors
Elucidating the non-radiative losses encountered in intramolecular charge transfer compounds with benzodithiophene-4,8-dione acceptors A new yellow-emitting quadrupolar donor–π–acceptor–π–donor (D–π–A–π–D) molecule compound has been synthesised featuring benzo-[1,2-c:4,5-c’]dithiophene-4,8-dione as the acceptor.
“我们正在创造自己的历史”：澳洲新唐人街的崛起
就在唐人街努力走出疫情时代的阴影，迈向崭新黄金时代之际，年轻一代却忙于打造属于他们自己的新文化枢纽。 English | Indonesian 作为在澳大利亚长大的华裔移民，陈月意（Elizabeth Chong）回忆童年时光时说，当时的墨尔本唐人街是一个能够让她重新确认自己的文化传统，并给她带来归属感的地方。 “[如今]是一个[和记忆中]大相径庭的地方了，我感到很陌生。” 点击进入全屏图文模式 上世纪30年代，3岁的陈月意从中国移民到了澳大利亚，如今她已经92岁了。 她被誉为“墨尔本唐人街的末代女皇”。她的家族与唐人街有着几十年的渊源，他的家族在唐人街开过餐馆，她自己从20世纪80年代起还在唐人街举办过各种美食节。 “但是现在我不清楚[唐人街]会走向何方。我感觉这已经不再是我所熟悉的那个的唐人街了，”她说。 这个“她所熟悉”的唐人街指的是位于墨尔本市中心曾经的华人聚居区——小博街（Little Burke Street）。 百余年来，这里一直是华人社区聚会、社交、用餐和文化庆典的中心。这里也是世界上历史最为悠久的一条唐人街。...
'We're building our own history': The fight for new Chinatown
As Chinatown struggles to return to its pre-COVID golden age, younger generations have been busy creating cultural hubs of their own. 中文版 | Indonesian As a Chinese immigrant growing up in Australia, Elizabeth Chong recalls the days when Melbourne's Chinatown was a place that reaffirmed her heritage and offered a sense of belonging. "I now feel almost like a stranger — that's a very funny feeling to me." Note: The current version of this story is not displaying as intended.
中国网红虐猫事件：超过十万人联名呼吁当局以“寻衅滋事罪”起诉博主 - ABC News
在中国引发舆论愤怒的网红“杰克辣条”因虐猫被当地派出所释放后，再度上传虐猫视频引发新一轮民愤。 警告：本文的一些描述恐引起部分读者不适，请选择性阅读。 目前，中国宠物领养平台“握爪”手机应用已发布五分告知书，呼吁公权力机关通过执法阻止虐待动物的行为，并组织律师团召开法律方面的专题研讨会。 该平台还收集了超过十万名中国网民的签名，联名要求阜南检方以“寻衅滋事罪”对虐猫者提起公诉。 发布虐猫视频的是29岁的中国安徽省的短视频博主徐志辉。他从四月中旬开始把一系列令人胆寒的虐待行为拍摄了下来了，并发布在网上。 徐志辉于4月27日凌晨被送至安徽阜南县城北派出所，遭到治安拘留。尽管他在微博上发表道歉声明，但有网民称他在5月7日再次在社交媒体平台直播虐猫。 在此之前，他以网名“@杰克辣条”经营着多个社交媒体账户，包括一个拥有40多万粉丝的Bilibili账户和一个拥有2万多粉丝的微博账户。 他的社交媒体日常发布的主要内容都是美食题材。 社交媒体掀起风暴 徐志辉虐猫的消息和视频通过社交媒体在中国和海外迅速传播。微博、抖音、TikTok和推特上的众多博主对此事表示震惊和声讨。...
留学生在澳洲打工限制即将恢复 生活成本和劳动力短缺恐加剧
朱咏霖在新冠疫情期间享受到了无工时限制带来的好处，每一周有三天在学校学习，还有三天的时间在小吃店和奶茶店工作，接近600澳元周薪让她能够应对悉尼飞涨的房租。 这位毕业于悉尼大学媒体专业的中国留学生将于今年七月开始攻读第二个学位——社会福利工作硕士。 但是，随着澳大利亚联邦政府计划在7月1日重新实施对国际学生签证持有人工作时长的限制，此举将会对朱咏霖这样的留学生的收入带来沉重打击。 她说，中国留学生从事的工作以咖啡厅、餐馆、零售店以及超市等为主，每小时的薪资不会很高。 如果未来工作的时间受到限缩，他们的日常开销更加捉襟见肘。 “悉尼的租金很疯狂，我当时差点儿要和六个人租一套房子，”她说，“现在我一间卧室的房租大概是400澳元，已经算是便宜的了。” “如果这个政策落实下来，我必须被迫去换一个时薪更高的工作，”她说。 “就我个人来讲，很讨厌这个政策。” 订阅中文简报 订阅ABC中文周报 网罗每周精选内容 Your information is being handled in accordance with the ABC Privacy Collection Statement.
新州选举：为什么多个华人选区抛弃了自由党？
上个周末落幕的新南威尔士州议会选举出现意外反转，现年43岁的新州工党领袖克里斯·米恩斯（Chris Minns）带领的工党赢得选举，成为新一任州长。 这是工党时隔12年后再次重新在新州执政。在华裔选民占比较高的选区，工党获得了的摇摆选票超出了观察人士的预料。 新州北部、西部和南部多个华人居民集中的选区，自由党在2019年获得的部分选票流向了工党和一些独立议员。 尽管一些选区的计票工作仍在进行，但华人中小生意经营者集中的Burwood、Eastwood、和Chatswood等地，自由党正呈现出失利的趋势。 此外，新任州长米恩斯胜选的Kogarah也拥有大量华裔选民，截至3月29日正午，该区18.5%的选票流向了工党。 相比之下，前州长多米尼克·佩罗特（Dominic Perrottet）在华人聚居区Epping的票数尽管领先，但也呈现了7.3%的选票流向工党的情况。 订阅中文简报 订阅ABC中文周报 网罗每周精选内容 Your information is being handled in accordance with the ABC Privacy Collection...
Effect of high-flow nasal cannula on patients’ recovery after inhalation general anesthesia
Abstract Objective: To investigate the effect of high-flow nasal cannula (HFNC) and Oxygen Nebuliser mask (ONM) on patients recovering from inhalation anesthesia. Methods: A retrospective analysis was performed on 128 patients after inhalation of general anesthesia in the recovery room of the Anesthesiology Department of The Fourth Hospital of Hebei Medical University from September 2019 to September 2021.
Grief-stricken relatives in Australia mourn loved ones killed in Türkiye-Syria earthquake as communities raise funds for victims
Inconsolable in his grief, Melbourne man Muhammed Velipasaoglu recounted how he learned that several of his family members were killed in the disastrous earthquake that struck Türkiye and Syria. "I've lost at least five of my relatives. My brother-in-law and his wife have passed. My cousin and his wife also passed away," he told the ABC. "My nephew and kids are badly injured, but the wife sadly died as well." Mr Velipasaoglu said many of the his relatives were at Osmaniye, a city near epicentre.
Students rush back to Australia after China bans online learning with foreign universities
Karen Zhang was taken by surprise when China issued an edict ordering all students studying with a foreign university online to return to in-person classes.
China's 'blunt' online university decision has students rushing back to ...
More than 40,000 Chinese university students are scrambling to return to Australia after China's government issued an order requiring them to ...
Xi Jinping tells Australia's governor-general ties between two countries moving ...
In a congratulatory message for Australia Day apparently only reported on in English-language Chinese media, President Xi Jinping says relations ...
Chinese President Xi Jinping tells Australian Governor-General David Hurley ties between two countries moving in 'right direction'
Chinese President Xi Jinping has said that relations with Australia were moving in the right direction in the latest sign of an improvement in ties between the major trading partners.
Australia has been left off the destination list for Chinese group tours. Some ...
After Australia imposed additional COVID-19 testing requirements on travellers from China, Beijing has left Australia off a list of 20 countries ...
After three years, Chinese tourists are free to travel again. But Australia may not be high on their list
After almost three years of closed borders, Chinese people are able to travel freely again from today. Data shows that online searches for visa applications and flight bookings have increased dramatically since authorities announced two weeks ago that travel restrictions would be lifted on January 8.
First arrivals from China after new COVID test rules land in Australia as Health Minister Mark Butler defends the move
The first people to fly into Australia after new COVID testing rules for travellers from China and Hong Kong were introduced have landed. From Thursday, people coming into the country from China, Hong Kong and Macau have to take a pre-departure COVID test and provide a negative result before departing. Cao Menghan, a Chinese Australian who has been waiting for her parents at Sydney Airport, told the ABC she was very excited for their arrival.
As the new year begins, many Australians are struggling to pay off their mortgages
Mobaraka Mohammadi says she works 12 hours a day just to make ends meet and pay off her mortgage. Ms Mohammadi, 23, from northern Adelaide, told the ABC she might have to stop university to pick up more hours if her mortgage repayments and living costs increased further. "I was actually trying to cut a few of my hours so I can concentrate on my study but … if I cut any hours, I'm not going to be able to pay my mortgage," she said.
Itching to buy an EV? Chinese manufacturing may make affordable electric vehicles an reality
阅读中文版 Henry He is one of eight million people in China who drive electric vehicles (EVs). The Shanghai resident bought his first EV in 2015 for about $20,000, to save money. "A major reason was that the rego was issued free of charge by the Shanghai local government when buying an EV," the 46-year-old told ABC News. "The auction price for a rego in Shanghai is generally about 100,000 yuan ($21,145).
Esra Ozkul - ABC News
This service may include material from Agence France-Presse (AFP), APTN, Reuters, AAP, CNN and the BBC World Service which is copyright and cannot be reproduced. AEST = Australian Eastern Standard Time which is 10 hours ahead of GMT (Greenwich Mean Time)
The world's two biggest emitters are coming together on climate - what can we expect from China-US talks?
The US and China have resumed formal climate talks for the first time since they were put on ice earlier this year when the relationship became strained over Taiwan. US President Joe Biden and China President Xi Jinping agreed to address climate change in their recent exchange in Bali, while top Chinese climate negotiator Xie Zhenhua and John Kerry, the US special presidential envoy for climate, did the same at COP27 in Egypt.
Chinese Communist Party hierarchy remains an all-boys club after more than a century
If all goessmoothly, it will be another "men in black" style group photo for the Chinese Communist Party's (CCP) new leadership after its 20th National Congress this week. In Beijing, the political struggle will be intense, and the power distribution will be mysterious, but one thing will be certain: no women will be elected to the CCP's top elite decision-making group led by General Secretary Xi Jinping.
'This must be a big joke': It wasn't until Albert gave up and moved overseas that Australia finally offered him a permanent visa
The federal government has followed through on a promise to fast-track visas for workers coming to Australia from overseas, but many migrants already in the country who remain on temporary visas are furious.
Spontaneous oxidation of I− in water microdroplets and its atmospheric implications
Spontaneous oxidation of I− in water microdroplets and its atmospheric implications† Dong Xing,a Xu Yuan,a Chiyu Liang,a Tianyun Jin,a Shuquan Zhang*b and Xinxing Zhang *a Abstract Atomic and molecular iodine, I˙ and I2, play important roles in the atmosphere, such as the catalytic depletion of ozone and the oxidation of gaseous elemental mercury. It is known that the major source of I˙ and I2 in the atmosphere is the photodissociation of organoiodine molecules released by algae in the sea.
Emerging degrader technologies engaging lysosomal pathways
Emerging degrader technologies engaging lysosomal pathways Yu Ding, *a Dong Xing, *b Yiyan Fei *c and Boxun Lu *a Abstract Targeted protein degradation (TPD) provides unprecedented opportunities for drug discovery.
'Just so overwhelming': Workers are scarce, so why is it so difficult to obtain a permanent visa in Australia?
Marina Shatalova has been trying for years to get enough points so the Australian government will let her stay permanently. "It has been a very emotional and difficult journey," she told the ABC. "I am Russian and there is no home for me in that country because of the political situation." With the unemployment rate at record lows, the federal government has made finding skilled workers from overseas a priority and promised to make the pathway to permanent residency easier.
The government has increased the skilled migrant cap to 195,000. So what do those who want or hold a visa think about it?
The federal government's decision to raise Australia's permanent migration cap by 35,000 has been welcomed by migrant workers and visa applicants but concerns have been raised about visa backlogs and worker exploitation protections. In an attempt to address economy-wide skills shortages, Home Affairs Minister Clare O'Neil said, the country would increase the cap to 195,000 this financial year.
Chinese tourists stranded in Tibet as coronavirus cases in China reach three-month high
Thousands of Chinese tourists have become stranded in Tibet as the region suffers a spike in coronavirus cases and provinces impose restrictions on travel from the area.
Would-be permanent residents living in Australia protest in frustration after overseas visa applicants get priority
Ragab Youssef was already frustrated by how long it was taking to process his application for a permanent residency visa.
NSW is reserving 20 per cent of selective school places for disadvantaged students, and some parents aren't happy about it
Thousands of NSW students are nervously awaiting the results of their selective school tests following a significant overhaul of the admissions process.
'The pressures are real': How the multiplying stresses on China's economy could affect Australians Original
Mr Zhao deposited his life savings into a bank in central China, but now can't access any of it. Key points: China's economy is under stress from banking sector issues and a property market decline The nation has also recorded its lowest quarterly growth rate since the 1990s Business leaders have differing views on how China's woes could impact Australia's economy The 44-year-old said his 1 million yuan ($217,000) had been frozen since April.
Chinese-Australian voters helped sway the election result. But there was a patchwork of reasons why
Along with millions of Australians, Anna Wang cast her vote for Labor this election. Key points: Some electorates with high Chinese-speaking populations saw big swings to Labor Many shared concerns about health, education and climate change But some say tensions with China shaped their vote too Her ballot was part of a massive swing towards Labor in the Sydney electorate of Reid, delivering the seat to Sally Sitou, who has Chinese heritage and whose parents fled Laos due to the Vietnam war.
Beijing locals buy fridge, stockpile food after Shanghai residents warn COVID outbreak will 'get serious'
Max Wan ordered a second fridge earlier this week and plans to stuff it with food for himself and his pets. The 39-year-old Australian screenwriter lives in Beijing, where health authorities are mass testing nearly 22 million people in a bid to control a COVID-19 outbreak. Mr Wan said he received text messages and phone calls from his friends in Shanghai who were enduring harsh lockdowns. They suggested he stock up on food.
'We may have a fight on WeChat': Chinese Australians divided over Ukraine-Russia war
After a recent discussion on the Ukraine-Russia war became heated and even "abusive" in her WhatsApp group for church members, Susie Su was forced to put a ban on the topic. The 69-year-old Taiwanese Australian, who helps to manage the social media group comprising some 50 Chinese Christians in New South Wales, said she wanted to maintain peace after realising the debate was dividing her community.
Russia's invasion of Ukraine sparks questions about China and Taiwan - but Taiwanese people aren't fazed
Valerie Kornieieva has watched on in horror at the war unfolding in her homeland of Ukraine. But she is also concerned for her second home, Taiwan, where she lives with her husband Stephen Xiao.
China accuses Australia of 'maliciously spreading disinformation' about laser shone at RAAF patrol aircraft
China says Australia's complaint about a laser from a Chinese naval vessel being directed at an Australian military aircraft does not square with facts.
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