Teming Zhang on Muck Rack

Teming Zhang

As seen in: eLife
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Articles

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor

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By Chenchen Mao, Yanyu Chen, Dong Xing, Teming Zhang
| eLife
eLife assessment This useful study draws on published single-cell and spatial transcriptomic data of colon cancer liver metastasis to clarify the pro- and anti-tumorigenic properties of NK cells. The authors discover increased GZMK+ resting NK cells in the tumor tissue and reduced abundance of KIR2DL4+ activated NK cells. However, the evidence is currently incomplete, as the models used to validate the hypothesis and claims are not adequate and lack the necessary controls.
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