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Dongmin J. Yoon

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Articles

Neural circuits regulating activity-based anorexia

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By Dongmin J. Yoon, Stephanie C. Dulawa
| Nature Verified
Abstract Evolutionarily conserved neural circuits evolved that mediate switching between feeding and foraging for food, depending on environmental conditions such as food scarcity and internal state [1,2,3]. Activity-based anorexia is a phenomenon observed ubiquitously in normal mammals that emerges under conditions of time-restricted food availability and continuous access to running wheels.
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The mitigation of activity-based anorexia by obese adipose tissue transplant is abolished by neonatal AgRP neuron ablation

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By Jie Zhang, Rizaldy Zapata, Martina Ulivieri, Avraham M Libster, Matthew McMurray, Olivia Osborn, Stephanie C. Dulawa, Dongmin J. Yoon
| Nature Verified
Abstract Anorexia nervosa (AN) is an eating disorder observed primarily in girls and women, and is characterized by a low body weight, hypophagia, and hyperactivity. The activity-based anorexia (ABA) paradigm models aspects of AN, and refers to the progressive weight loss, hypophagia, and hyperactivity developed by rodents subjected to fixed-time food restriction and running wheel access.
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