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Dongpei Li

As seen in: BioRxiv
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Articles

Gangliosides in neural stem cell fate determination and nerve cell specification--preparation and administration

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By Yutaka Itokazu, Toshio Ariga, Dongpei Li, Fuchigami Takahiro
| BioRxiv
Abstract Gangliosides are sialylated glycosphingolipids with essential but enigmatic functions in healthy and disease brains. GD3 is the predominant species in neural stem cells (NSCs) and GD3-synthase (sialyltransferase II; St8Sia1) knockout (GD3S-KO) revealed reduction of postnatal NSC pools with severe behavioral deficits including cognitive impairment, depression-like phenotypes, and olfactory dysfunction.
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Dietary Isomers of Sialyllactose Increase Ganglioside Sialic Acid Concentrations in the Corpus Callosum and Cerebellum and Modulate the Colonic Microbiota of Formula-Fed Piglets

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By Tanya Yatsunenko, South San Francisco, Sheila K Jacobi, Dongpei Li, Somsankar Dasgupta
| The Journal of Nutrition Verified
Background: Sialyllactose is a key human milk oligosaccharide and consists of sialic acid (SA) bound to a lactose molecule. Breastfed infants have increased accumulation of ganglioside-bound SA compared with formula-fed infants. Objective: This study aimed to determine whether different isomers of sialyllactose enrich brain SA and modulate the microbiome of developing neonatal piglets.
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