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Donovan Whitfield

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Redox regulation by sulfiredoxin-1: bridging cysteine oxidation and liver disease therapeutics - Experimental & Molecular Medicine

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By Jong-Won Kim, Donovan Whitfield, Gu Seob Roh
| Nature
Abstract Cysteine (Cys) posttranslational modifications play a critical role in regulating protein function, cellular signaling and redox homeostasis in various physiological and pathological conditions. Sulfiredoxin-1 (SRXN1) has emerged as a key regulator of protein redox homeostasis through its involvement in Cys sulfinylation. However, the role of SRXN1 in the pathogenesis of diseases and its therapeutic implications have yet to be fully explored.
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