Doug Quackenbush

Abstract High-content imaging (HCI) provides a rich snapshot of compound-induced phenotypic outcomes that augment our understanding of how compounds affect cellular systems. Generative imaging models for HCI provide a route towards anticipating the phenotypic outcomes of chemical perturbations in silico at unprecedented scale and speed.

Loading metrics Open Access Peer-reviewed Research Article Abstract The importance of human cell-based in vitro tools to drug development that are robust, accurate, and predictive cannot be understated. There has been significant effort in recent years to develop such platforms, with increased interest in 3D models that can recapitulate key aspects of biology that 2D models might not be able to deliver.