D.S-W. Tan on Muck Rack

D.S-W. Tan

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Genetic landscape of patients with ALK-rearranged non-small-cell lung cancer (NSCLC) and response to ceritinib in ASCEND-1 study

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By M. A. Thomas, D-W. Kim, D.S-W. Tan, Onkologie der Thoraxtumoren
| Lung Cancer
Highlights • We explored the role of NGS in improving our understanding of response to ceritinib. • Genomic profiles of ALK inhibitor resistance are diverse. • The driver resistance mechanisms include ALK TKD mutations and/or non-ALK lesions. • Passenger mutations may also contribute to ALK resistance mechanisms. • Molecular profiles can be used to detect tractable targets driving drug-resistance.
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