Duanchen Ding

Graphical Abstract Abstract The reactivity of a carbon-centered σ,σ,σ,σ-type singlet tetraradical containing two meta-benzyne moieties, the 2,4,5,7-tetradehydroquinolinium cation, was examined in the gas phase toward dimethyl disulfide, cyclohexane and allyl iodide. The major reactions were thiomethyl radical abstraction, H atom abstraction and allyl radical abstraction, respectively. The reactivity of this tetraradical was found to be greater than that of the relevant meta-benzyne biradicals.

DNA encoded library (DEL) technology allows for rapid identification of novel small-molecule ligands and thus enables early-stage drug discovery. DEL technology is well-established, numerous cases of discovered hit molecules have been published, and the technology is widely employed throughout the pharmaceutical industry.