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Articles

Genetic background sets the trajectory of experimental cancer evolution

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By Sarah Aitken, Frances Connor, Christine Feig, Tim Rayner, Margus Lukk, Juliet Luft, Stuart Aitken, Claudia Arnedo-Pac, James Hayes, MIchael Nicholson, Ailith Ewing, Vasavi Sundaram, Jan C. Verburg, John Connelly, Mikaela Behm, Susan Campbell, Maelle Daunesse, Elissavet Kentepozidou, Oriol Pich, Aisling M. Redmond, Inés Sentís, Lana Talmane, Paul Flicek, Nuria Lopez-Bigas, Colin A. Semple, Martin Taylor, Duncan Odom, Javier Santoyo-Lopez
| Nature Verified
Abstract Human cancers are heterogeneous1. Dissecting how germline genetic variation and environmental factors shape tumour evolution using human datasets is limited by inherent diversity in genetic backgrounds2 and environmental exposures3,4,5. Here, to overcome these limitations, we re-ran early tumour evolution hundreds of times in diverged inbred mouse strains, generating matched histology and whole-genome and transcriptome sequences.
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