Dunhuang Wang

Abstract Introduction Intensive cancer treatment with nanoplatform is widely exploited in the clinic, the emerging nanomedicine offers an unparalleled opportunity for encapsulating potential antitumor drugs in a nano-carrier. Apoptin (AP), a coding protein of VP3 gene, stem from the chicken anemia virus (CAV), can be activated in malignant cells selectively and prevents the dividing cancer cells from repairing their DNA lesions, thereby forcing them to undergo apoptosis.

Zhenzhen Luo,1,* Dunhuang Wang,2,* Lie Lin,2 Rui Zhou,2 Yuanyuan Su,2 Zongkai Zhang,2 Jing Hu,2 Yaqing Dai,2 Jingjing Wu,2 Xiaoyan Huang,2 Yufei Zhou,2 Liuyun Gong2 1Shenzhen Cancer Hospital, Chinese Academy of Medical Sciences, Shenzhen, Guangdong, 518000, People’s Republic of China; 2Department of Radiation Oncology, Xiamen Cancer Quality Control Center, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of...