Durdu Altuner

Abstract One of the side effects of hydroxychloroquine is ototoxicity. This study examined the effect of adenosine triphosphate (ATP) on ototoxicity in rats treated with hydroxychloroquine (HCQ). In this study, 24 rats (male, albino Wistar) were used. The animals were divided into four groups: healthy control group (HG), ATP alone group (ATPG), HCQ alone group (HCQG), and ATP + HCQ (AHQG) group. The ATPG and AHQG groups were injected with ATP intraperitoneally (IP) at a dose of 4 mg/kg/day.

2. Material and Methods 2.1. Animals A total of 66 5–6-month-old albino male Wistar rats, each weighing between 345 and 360 g, were used in this experiment. All the experimental animals were obtained from Erzincan Binali Yıldırım University Experimental Animals Application and Research Center. To acclimatize the animals to the experimental environment, each group was housed in a separate cage at normal room temperature (22 °C) and fed ad libitum.

DISCUSSION The effect of TPP against the oxidative damage created in the brain with I/R was investigated biochemically. In the study of Cakir et al.21, I/R model was created by placing a clip on the common carotid artery21.