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Durmus Hatipoglu on Muck Rack

Durmus Hatipoglu

As seen in: Nature
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Articles

Innovative design and comprehensive characterization of a valine-enhanced lipid nanoparticle-coated mRNA vaccine targeting the SARS-CoV-2 S-RBD antigen | Scientific Reports

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By Tugce Duran, Naci Çine, Mehmet Ali Karaselek, Serkan Küççüktürk, Mehmet Burak Ateş, Durmus Hatipoglu, Umran Calıskan
| Nature Verified
Abstract The SARS-CoV-2 pandemic has led to major advances in mRNA vaccine development. This study aimed to develop a cationic lipid nanoparticle (LNP) coated mRNA vaccine targeting the receptor binding domain (RBD) against the SARS-CoV-2 virus and adding valine to the N-terminal end to increase its stability, and to comprehensively characterize the physical, thermal, microscopic and biological properties of vaccine.
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