Duxin Li on Muck Rack

Duxin Li

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Articles

DC-CD4 bispecific tolerogenic nanovesicles induce antigen-specific regulatory T cells and ameliorate collagen-induced arthritis in mice

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By Lei Zhao, Ze Yuan, Xiaodie Yang, Jie Pan, Yiran Zheng, Xinyun Zhang, Zhongqiang Gao, Duxin Li, Yunli Yu
| Nature Verified
Abstract Inducing antigen-specific regulatory T (Treg) cells is a promising strategy for treating autoimmune diseases (AID). Here, we present dendritic cells-CD4⁺ T cells (DC-CD4) bispecific tolerogenic nanovesicles (NV) co-loaded with an antigenic peptide and rapamycin. We show that these NVs bring DCs and CD4⁺ T cells into close spatial proximity through CTLA4-CD80/86 and anti-CD4 (aCD4)-CD4 interactions, thereby promoting antigen-specific Treg cell generation.
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